The research behind Super Synbiotics - Supersynbiotics UK
Research

Synbiotic 2000

Synbiotic® Food Supplement – a result of Synbiotic 2000

For many years Professor Stig Bengmark has conducted research about the role of inflammation and the intestinal flora when illness occurs. In 1999 Professor Bengmark launched a project together with some research colleagues, in which they collected 535 different lactic bacteria. Their goal was to find an elite among anti-inflammatory bacteria. They studied the bacteria’s ability to produce antioxidants, anti-inflammatory proteins and, in particular, anti-inflammatory cytokines and their ability to induce protective beta-defensin. A special interest was put on the bacteria’s ability to enhance each other’s anti-inflammatory characteristics. The composition was named Synbiotic 2000®, and early studies on animals showed its unique characteristics to fight inflammation and protect body tissue from damage.

For more than 15 years Synbiotic 2000® has been studied all over the world, on everything from IBS, HIV, cancer patients and liver transplantations. At this moment Synbiotic 2000® is included in a study on patients with ADHD at Karolinska Institutet, Stockholm, and in a study on critically ill patients with liver disease at The University of Sydney Hospital. Time after time Synbiotic 2000® has proven successful in reconditioning the intestinal flora and strengthening the immune system of seriously ill people, often in intensive care. The clinical studies indicate a dramatic reduction of life-threatening infections after major abdominal surgeries such as liver transplantations and serious accidents. Treatment with Synbiotic 2000 has resulted in significantly fewer infections, and it reduces complications after surgery. One study indicated that infections after a liver transplant decreased from 51% to 3% when Synbiotic 2000 was used. Another study showed similar results in regards to infections among patients who had been in acute and serious accidents. In this study, the level of infections decreased from over 50% to 14% (Read the full study here).

Studies show that the bacterial strains in the composition complement each other. An important aspect when probiotics is given to humans, is that it must be able to survive the move through the gastrointestinal tract, and that it can colonise and stay on the mucous membrane in the intestines for at least a day, but preferably several weeks. Studies on the bacterial strains in Synbiotic 2000® show that they meet this criterion.

Synbiotic® Food Supplement is a variant of Synbiotic 2000®. It consists of the four bacteria (L. Plantarum, L. Paracasei, Pediococcus and Leuconostoc) in a composition with 4 grams of bioactive fibres, which help the 15 billion bacteria in the composition to quickly multiply in the gastrointestinal tract. Two of the selected bacterial strains in Synbiotic15, L plantarum and L paracasei, have proved to be key components in the intestinal flora in individuals who haven’t adopted a Western lifestyle. For the majority of us, these strains are missing in our gastrointestinal tract. This is especially true for those suffering from obesity, and it leads to a significantly higher risk of developing a variety of chronic diseases.

Research articles

01. Pre-, pro- and synbiotics 02. Probiotics in health and disease 03. Synbiotic control of inflammation and infection in transplantation 04. Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis 05. Synbiotics to strengthen gut barrier function and reduce morbidity in critically ill patients 06. Probiotics partly reverse increased bacterial translocation after simultaneous liver resection and colonic anastomosis in rats 07. Acute and "chronic" phase reaction - a mother of disease 08. Mediated induction of human beta-defensin 2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium 09. Bioecologic control of the gastrointestinal tract: the role of flora and supplemented probiotics and synbiotics 10. Bio-ecological control of acute pancreatitis: the role of enteral nutrition, pro and synbiotics 11. Synbiotics and the mucosal barrier in critically ill patients 12. Bioecological control of organ failure: the role of enteral nutrition, probiotics and synbiotics 13. Probiotics: a practical review of their role in specific clinical scenarios 14. Prebiotics and synbiotics in clinical medicine 15. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation – a randomized, double-blind trial 16. Subcutaneous administration of live lactobacillus prevents sepsis-induced lung organ failure in rats 17. Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective randomized, double-blind study 18. Impact of nutrition on ageing and disease 19. Pretreatment with pro- and synbiotics reduces peritonitis-induced acute lung injury in ratswith pro- and synbiotics reduces peritonitis-induced acute lung injury in rats 20. Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients 21. Bio-ecological control of perioperative and ITU morbidity 22. Bioecological control of inflammatory bowel disease 23. Synbiotic-associated improvement in liver function in cirrhotic patients: relation to changes in circulating cytokine messenger RNA and protein levels 24. Effect of enteral nutrition and Synbiotics on bacterial infection rates after polyrus-preserving pancreatoduodenectomy 25. Synbiotics in human medicine 26. Bio-ecological control of chronic liver disease and encephalopathy 27. Pro- and Synbiotics to control inflammation and infection in patients with multiple injuries 28. Benefits of a synbiotic formula in critically ill trauma patients: early results of a randomized controlled trial 29. Effects of pre- and probiotics on liver regeneration after resection – a randomized double-blind pilot study 30. Pro- and Synbiotics to prevent sepsis in major surgery and severe emergencies 31. Integrative medicine and human health – the role of pre-, pro- and Synbiotics 32. Processed foods, dysbiosis, systemic inflammation, and unhealth 33. Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection 34. Gut microbiotia, immune development and function 35. Synbiotic treatment reduces intestinal dysbiosis, prevents inflammation and infections in chronic kidney disease – an efficient supplement to dialysis and transplantation? 36. Supplementation with Synbiotics and/or branched chain amino acids in hepatic encephalopathy: a pilot randomized placebo-controlled clinical study 37. Effects of a synbiotic on symptoms and daily functioning in attention deficit hyperactivity disorder – a double blind randomized controlled trial

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